Spain's Azahara Munoz shot an opening-round seven-under 65 to claim the HSBC Women's Champions 2013 outright lead in Singapore.
Playing in the first group of the day at Sentosa Golf Club's Serapong Course, Munoz made seven birdies in a flawless round to top the leaderboard on Thursday.
Americans Stacy Lewis and Lizette Salas, Sweden's Karin Sjodin, Thailand's Pornanong Phatlum and South Korean Sun Young Yoo were tied for second place at five-under 67.
Another American, Paula Creamer, was a further stroke back after a 68, despite injuring her right shoulder in a car crash in Thailand on Sunday.
The crash, which also involved fellow LPGA players Ai Miyazato and Suzann Pettersen, happened as the trio were travelling to the airport in Bangkok to catch their flights to Singapore.
Creamer was in a four-way tie for seventh with world number one Yani Tseng, Danielle Kang and Chella Choi.
Defending champion Angela Stanford struggled to a four-over 76.
Karrie Webb, tied for 29th, and Katherine Hill-Kirk, tied for 54th, are Australia's two entrants.
The sixth annual tournament features 17 of the top 20 players in the world.